Ocular immune privilege
نویسندگان
چکیده
The eye attempts to limit local immune and inflammatory responses to preserve vision. This phenomenon, known as ocular immune privilege, is mediated by a combination of local and systemic mechanisms. While immune privilege is believed to protect the eye from day-to-day inflammatory insults, it is not absolute and its mechanisms are still incompletely understood.
منابع مشابه
Ocular Immune Privilege and Ocular Melanoma: Parallel Universes or Immunological Plagiarism?
Evidence of immune privilege in the eye was recorded almost 140 years ago, yet interest in immune privilege languished for almost a century. However, the past 35 years have witnessed a plethora of research and a rekindled interest in the mechanisms responsible for immune privilege in the anterior chamber of the eye. This research has demonstrated that multiple anatomical, structural, physiologi...
متن کاملOcular Immune Privilege and Transplantation
Allografts are afforded a level of protection from rejection within immune-privileged tissues. Immune-privileged tissues involve mechanisms that suppress inflammation and promote immune tolerance. There are anatomical features, soluble factors, membrane-associated proteins, and alternative antigen-presenting cells (APC) that contribute to allograft survival in the immune-privileged tissue. This...
متن کاملInterleukin-1 receptor antagonist suppresses Langerhans cell activity and promotes ocular immune privilege.
PURPOSE To determine whether the capacity of Langerhans cells (LCs) to abrogate ocular immune privilege can be suppressed by the topical application of interleukin-1 receptor antagonist (IL-1ra). METHODS Cautery was applied to corneas of BALB/c mice on day 0 to induce centripetal migration of LCs. Immune privilege was tested by the ability to induce anterior chamber-associated immune deviatio...
متن کاملMechanisms of immune privilege in the anterior segment of the eye: what we learn from corneal transplantation
The eye, like the brain and reproductive organs, possesses inherent immune privilege, and inflammation is self-regulated so as to preserve the organ functions. Studies over the past 30 years have provided insights of the multiple mechanisms of immune privilege. At present, three major lines of thought prevail regarding the molecular mechanisms of immune privilege in the eye: there are (1) anato...
متن کاملThe retinal pigment epithelial cells modulate phagolysosome activation in macrophages through neuropeptides, a-MSH and NPY
Objective: The main function of the human eye is to detect light, motion, and color from our surroundings. This information is then processed and translated in the brain as vision. However, what is less known about the eye is its ability to regulate immune function. It is this ocular immune privilege that maintains the eye’s ability collect visual information. The degeneration of immune privile...
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